I have AS and sjogren's syndrome. I've tried several tnf inhibitors and most recently remicade and rituxin. The meds make me lose my appetite (down 12 lbs - too much for me) and make me sleep about 16 hours a day. My rheumatologist seems confused as to why they are causing these symptoms. I'm also on prednisone and still losing weight. Does anyone else have these side effects from these medicines?