I take naproxen 500mg twice a day, to spread the dosage and cover morning and evening better, after previously trying diclofenac, meloxicam and etoricoxib previously, none of which did a lot or had too many side effects. I found it an enormous help for the first year or so. Have now been on it for over 4 years, and it helps less and less with pain and stiffness, but still very good when I think what I was like before it. So maybe the effects do wear off as we get used to it from that experience. Also I find with each flare-up being different, it can be hard to keep up with it's effectiveness sometimes too. I suppose for heavy pain it may only be able to reduce it anyway and not take it away.. I now take sulfasalizine to smooth over the pain I was getting that naproxen can no longer touch, though I don't know that this isn't just because the condition is worsening perhaps, and not the fault of the naproxen...?

Sleeping and/or sitting still is hard on our joints.  It is the "tell" that helps differentiate inflammatory pain from mechanical pain.  On other boards, I have heard people talk about setting alarms to take more pain medicine during the night - before the pain wakes them up, so they get those extra hours of sleep.  I do that now, myself, when I am flaring pretty bad.  Works like a charm.  You would think that waking yourself to take a pill would make you lie awake.  For some people it might.  But, for me it allows me to sleep the rest of the night and I wake up feeling more rested.  It is worth it!

Naproxen works 8-12 hours.

When discussing how long medications will be effective remember that the time frames that are given are based upon statistical averages with allowances made based on the risk of overdose. Your body sheds off the active ingredient somewhat like radioactive materials decay, but not as precisely. Every drug, as part of FDA acceptance procedure, is supplied with a curve describing how fast it gets into the system and how quickly the body eliminates it. This curve is derived under strict guidelines that probably don't exactly mirror yourself and even varies between different generics and name brands. Unfortunately no 2 bodies are the exact same with respect to absorption, nor are they the same in terms of the amount necessary to provide relief. Add in the fact that the disease is not exactly as bad today as it was last month and trying to have specific expectations is a hopeless cause. Be happy that you sleep better than you did and that's all you can hope for.

I take naproxen in the morning, one 250 mg tablet. It keeps me going most of the day, but before dinner I am feeling the pain again. However, I avoid taking anything else. About an hour before bed I take two 10 mg tablets of Tryptizol. This is an anti-depressant that works on AS.I sleep well for six hours but then I must get up. More that two of these does let me sleep long, but, I feel groggy and depressed the whole day.  So currently this is my limit. I have been taking Trypizol since October. Six hours of good sleep is ok for me now. I am retired so I can rest during the day.

Yes I have noticed this not had this problem for many years now but I think it my medication I have just gone on Tamadol never had these before now I am sat here when the rest of england are in bed. We have the grandchildren at weekends so can not walk around like a bear with a sore head.back to you all i can think about your problem is it must something to do with your med think you need to see your doctor & try work something out you need your sleep the days are long this is what i shall be doing very soon wish you luck & aork something out ...

I too take naproxen (2 Aleve pills) before bedtime, before it used to last a good 9 hours. Now i cant go 5 hours without starting to feel uncomfortable again. I think it's because our bodies got used to the meds. When i sleep i have pain in my rib cage (so laying on my back is a no-no), in my knees (i can't put my knees together when i sleep sideways) and my neck feels horrible either way! The naproxen alleviates a bit of it but i still feel it most of the time. I have an appointment with my rheumatologist in July, hoping he will help me out with nighttime, because day time is already bad as is, we don't need bedtime to be unbearable! Good luck to you, i feel your pain :)