Neil Golder

Has the Humira stopped working? Feel like i've been run over and haven't noticed a lot of difference after taking the last three shots. I used to get a sense of wellbeing after the jabs for about a week but now nothing. Anybody else experienced this? Thanks all.

Asked by Neil Golder 3 years ago humira




Elizabeth Winchell
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Any of the TNFs can, for some folks, stop working.  If it feels like Humira is not doing the job any more, there's certainly reason to believe you're right.

by Elizabeth Winch...  3 years ago

Carmen
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Yeah i feel the same, I almost feel like not taking the next shot, because I don't think it's doing anything and I am starting to feel worse. Have to see what my Rheumy says, next appointment isn't until Jan. It's a waiting game. I wish I could take anti-inflammitories I know they work for getting rid of the pain.

by Carmen 3 years ago

Jackie Aitchison
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I was on enbrel for several years and it made a huge difference, then I had to come off it for a year. I started again, and it did nothing. So we decided to try Humira, it too did nothing, so have come off it too. No reason, no explanation, just stopped being effective.

by Jackie Aitchiso...  3 years ago

Ginny Reel
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I had the same problem with Humira. It worked great for me for a while - then suddenly it just stopped. Around the same time, I noticed my lymph nodes were hugely swollen for a day or two after the shots. I didn't connect the two until my rheumy said that I may have developed an immune response to the drug. He suspected that my immune system was zapping the TNF binders before they could do their work. I switched to simponi and had the same problem. He recommended using a drug to inhibit immune response but I couldn't afford it since it was not covered by insurance. I have had some luck with enbrel and arava as a combo.

by Ginny Reel 3 years ago

Kathryn
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There is a possibility that your immune system (which is designed to be adaptive, unfortunately for us!) has evolved to "ignore" the drug. If this is the case, switching to a different biologic may help you.

However, I started feeling the same thing you described; that the meds, which used to make me feel noticeably better, stopped making me feel better. My rheumatologist checked me out and told me the drug was still preventing the joint damage, but not the pain-causing inflammation (which I don't quite understand... Isn't the damage due to inflammation?). He put me back on celebrex (anti-inflammatory) and I've felt much better since.

by Kathryn 3 years ago

Jerry Grynspan
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Actually it is very common for 2 reasons. First is that the disease, just seems to adapt around it and no one knows why. Second is that even though it has kept you comfortable for some time, the disease still was causing damage and now you're feeling the damage.

by Jerry Grynspan 3 years ago

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Has the Humira stopped working? Feel like i've been run over and haven't noticed a lot of difference after taking the last three shots. I used to get a sense of wellbeing after the jabs for about a week but now nothing. Anybody else experienced this? Thanks all.

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